what is the current state of genomic sequencing and what are the future technologies that will be used in clinical settings to further personalized medicine?;Attachment Preview;Diagnostics outline.docx Download Attachment;Diagnostics;1. Epigenetics (<3 pages) - Vikram;Subtopics: Description, Current State of Research, Future Directions and Applications;A. I will discuss the current applications of epigenetics as well as propose a;future direction for the use of epigenetics in a diagnostic manner.;Advances in the understanding of epigenetics as well as the completion;Human Genome Project has led to an abundance of personalized data.;The use of this science and advances in informatics allows for new;opportunities to integrate new technologies with diagnostics and;therapeutics.;B. Discuss the molecular basis of epigenetics, specifically chromatin;immunoprecipitation.;a. DNA methylation and chromatin remodeling;b. Structural inheritance systems;c. Discuss how epigenetics can play a role in Angelman syndrome;and Prader-Willi syndrome;C. Present how the use of bioinformatics methods are playing an increasing;role in computational epigenetics;D. Discuss some chromosomal abnormalities and how epigenetics is;associated with it.;a. Inversions (both de novo and familial);1.Advancing Clinical Utility of Genomics with Technology (<3 pages) - Vikram;Subtopics: Background Information, Current State of the Informatics, Future Directions;I will discuss the current state of DNA sequencing specifically discussing the;current shortcomings in this field. In addition I will discuss the future direction of;this technology touching base on products like the GeneChip and other DNA;microarray devices as well as how they will be implemented in the evolving;informatics field.;A. Obtaining sequencing data has gotten faster and less expensive, but bottlenecks exist not;just in regulatory process but also in correlating DNA sequence with clinical outcomes. A;key driver for the future is advancement of clinical utility for other genes with advances;in the bioinformatics pipelines and data management. Major players in sequencing;technologies are already offering data analysis and data storage cloud services in addition;to just the instrumentation. New technologies that break the bottleneck in analysis and;drive clinical utility of additional genes will be crucial to advancing the translation of;sequencing to the clinic;B. Discuss current products especially the GeneChip;C. Discuss the benefits of sequencing specifically in the prenatal setting.;A.a.;Verinatas non-invasive method to determine chromosomal;abnormalities;Limitations;1. Sequencing Cost (0.5 pages) - Vikram;Subtopics: Description of Sequencing Cost, Insurance Coverage, Legislation;I will discuss the costs and availability associated with human whole-genome;sequencing. I will also provide details on insurance coverage, research funding;and other methods of payment for sequencing, as well as any legislation related to;whole-genome sequencing of the general public.;A. I will also discuss the advantages/disadvantages of various methods of;single-molecule real-time sequencing
what is the current state of genomic sequencing and what are the future technologies
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